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Maryland covid deaths june 20219/26/2023 Knowledge about VITT continues to evolve, and updates will be made as new data become available. Consider referral to tertiary care center if VITT is confirmed.Avoid platelet transfusions unless other treatments have been initiated AND life-threatening bleeding or imminent surgery.If thrombocytopenia but no thrombosis and negative PF4 ELISA: likely ITP (see Q4).If thrombocytopenia and very high D-Dimer in absence of known thrombosis, particularly in the presence of severe headache, check PF4 ELISA, and consider treatment (see Q2).If PF4 ELISA returns negative and there is no thrombocytopenia, VITTis ruled out treat as standard venous thromboembolism. Confirmed thrombosis AND at least one of the following.Initiate therapy with intravenous immunoglobin and nonheparin anticoagulation pending PF4 ELISA results if:.PF4-ELISA (HIT assay) draw blood prior to any therapies.Imaging for thrombosis based on signs/symptoms.CBC with platelet count and peripheral smear. ![]()
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